Genre: Mystery

Dr. House takes Cuddy's challenge to go off his painkillers for a week, but the effects of his withdrawal symptoms may put his patient in danger.

Dr. House and the team treat a homeless woman whose worsening symptoms and unknown identity prove to be a complex mystery.

House has to defend himself when he treats a patient who has legally chosen to refuse treatment.

House and his team have to act fast when a high school student is admitted with a mysterious and lethal poisoning, especially when they discover more teens have been diagnosed with the same deadly illness.