Genre: Mystery

Chase's religious faith bubbles to the surface when he treats a young nun. In addition, he and House reach a fundamental disagreement about the patient that may finally end Chase's reputation as House's "yes man" but also bring's House's methods, reputation and objectivity are given more serious scrutiny.

House and his team are placed under review after a staff member gets hurt.

Facing a 6-month jail term, and the realization that he won't be there for Wilson at the end, House finds himself examining his entire life while contemplating a dismal future without his best friend.

The team takes on the case of Derrick, a 19-year-old college student who had a mysterious nose bleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother’s voice in his head. Meanwhile, Foreman tries a different approach with House.