Event Year: 2004

When doctors are unable to diagnose why a severely autistic boy screams loudly for no apparent reason, House takes the case. As the boy's condition worsens, it becomes obvious that House relates to the boy because he has no social niceties.

House puts a well-known medical researcher through a battery of tests to determine why he collapsed in his lab. When the team is unable to diagnose the problem, the doctor asks the team to help him end his life. House is forced to use his cane again after the ketamine has worn off as he deals with a clinic patient's teenaged daughter who has a crush on him.

House and the team treat a young boy who claims there is a tracking device in his neck and believes he has been the subject of alien experimentation. Cameron is outraged when she learns Cuddy and Wilson have been lying to House about the diagnosis on his last case.

After recovering from his gunshot wounds, House works feverishly on two cases at the same time: a paralyzed man who drove his wheelchair into a swimming pool and a woman who became paralyzed after a yoga session.