Westmoreland wants Michael to speed up the planned escape, and gets Bellick one step closer to unraveling it. Michael has to decide whether to involve Sara in the breakout plan. Tweener's devotion is put to a test. Veronica finds out that her ally unexpectedly has a connection to an inmate serving time at Fox River.
Show: Prison Break
Due to a political conspiracy, an innocent man is sent to death row and his only hope is his brother, who makes it his mission to deliberately get himself sent to the same prison in order to break the both of them out, from the inside out.
Go
Everyone's ready to make their escapes across the high wire. Veronica and Nick realize they may be in over their heads. And Agent Kellerman helps Vice President Reynolds calm down before her debate.
Flight
As the escape is in progress, Warden Pope and Captain Bellick begin a search to detain the escapees. Michael and co. have to reach the aircraft fast as the police is hot on their heels. Veronica discovers a major piece of evidence that could prove Lincoln's innocence. The Vice President is worried about losing her authority.
Manhunt
As eight hours has passed since the escape, Michael, Lincoln, Sucre, C-Note and Abruzzi attempt to evade their seekers. Bellick is forced to relinquish the command of the search party to FBI Special Agent Alexander Mahone whose ingenious approach makes Michael's life as a fugitive harder. As a result from her overdose, Dr. Tancredi is in critical condition. A short-handed T-Bag faces the ultimate challenge.